神经网络是高维非线性动力学系统，通过许多相互连接的单元的协调活动来处理信息。了解生物学和机器学习网络的功能和学习如何需要了解这种协调活动的结构，该信息包含在单元之间的跨跨构象中的信息。尽管动态平均场理论（DMFT）阐明了随机神经网络的几个特征，特别是它们可以产生混乱活动，但现有的DMFT方法不支持跨跨化的计算。我们通过通过两点腔法扩展DMFT方法来解决这个长期存在的问题。这首先揭示了活动协调的几个空间和时间特征，包括有效维度，定义为协方差矩阵频谱的参与率。我们的结果提供了一个一般的分析框架，用于研究随机神经网络中集体活动的结构，更广泛地，在具有猝灭障碍的高维非线性动力学系统中。

Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the heterogeneity of presentation of geriatric depression suggests that multiple biological mechanisms may underlie it. Current biological research on LLD progression incorporates machine learning that combines neuroimaging data with clinical observations. There are few studies on incident cognitive diagnostic outcomes in LLD based on structural MRI (sMRI). In this paper, we describe the development of a hybrid representation learning (HRL) framework for predicting cognitive diagnosis over 5 years based on T1-weighted sMRI data. Specifically, we first extract prediction-oriented MRI features via a deep neural network, and then integrate them with handcrafted MRI features via a Transformer encoder for cognitive diagnosis prediction. Two tasks are investigated in this work, including (1) identifying cognitively normal subjects with LLD and never-depressed older healthy subjects, and (2) identifying LLD subjects who developed CI (or even AD) and those who stayed cognitively normal over five years. To the best of our knowledge, this is among the first attempts to study the complex heterogeneous progression of LLD based on task-oriented and handcrafted MRI features. We validate the proposed HRL on 294 subjects with T1-weighted MRIs from two clinically harmonized studies. Experimental results suggest that the HRL outperforms several classical machine learning and state-of-the-art deep learning methods in LLD identification and prediction tasks.

Since early in the coronavirus disease 2019 (COVID-19) pandemic, there has been interest in using artificial intelligence methods to predict COVID-19 infection status based on vocal audio signals, for example cough recordings. However, existing studies have limitations in terms of data collection and of the assessment of the performances of the proposed predictive models. This paper rigorously assesses state-of-the-art machine learning techniques used to predict COVID-19 infection status based on vocal audio signals, using a dataset collected by the UK Health Security Agency. This dataset includes acoustic recordings and extensive study participant meta-data. We provide guidelines on testing the performance of methods to classify COVID-19 infection status based on acoustic features and we discuss how these can be extended more generally to the development and assessment of predictive methods based on public health datasets.

To analyze this characteristic of vulnerability, we developed an automated deep learning method for detecting microvessels in intravascular optical coherence tomography (IVOCT) images. A total of 8,403 IVOCT image frames from 85 lesions and 37 normal segments were analyzed. Manual annotation was done using a dedicated software (OCTOPUS) previously developed by our group. Data augmentation in the polar (r,{\theta}) domain was applied to raw IVOCT images to ensure that microvessels appear at all possible angles. Pre-processing methods included guidewire/shadow detection, lumen segmentation, pixel shifting, and noise reduction. DeepLab v3+ was used to segment microvessel candidates. A bounding box on each candidate was classified as either microvessel or non-microvessel using a shallow convolutional neural network. For better classification, we used data augmentation (i.e., angle rotation) on bounding boxes with a microvessel during network training. Data augmentation and pre-processing steps improved microvessel segmentation performance significantly, yielding a method with Dice of 0.71+/-0.10 and pixel-wise sensitivity/specificity of 87.7+/-6.6%/99.8+/-0.1%. The network for classifying microvessels from candidates performed exceptionally well, with sensitivity of 99.5+/-0.3%, specificity of 98.8+/-1.0%, and accuracy of 99.1+/-0.5%. The classification step eliminated the majority of residual false positives, and the Dice coefficient increased from 0.71 to 0.73. In addition, our method produced 698 image frames with microvessels present, compared to 730 from manual analysis, representing a 4.4% difference. When compared to the manual method, the automated method improved microvessel continuity, implying improved segmentation performance. The method will be useful for research purposes as well as potential future treatment planning.

在许多情况下，更简单的模型比更复杂的模型更可取，并且该模型复杂性的控制是机器学习中许多方法的目标，例如正则化，高参数调整和体系结构设计。在深度学习中，很难理解复杂性控制的潜在机制，因为许多传统措施并不适合深度神经网络。在这里，我们开发了几何复杂性的概念，该概念是使用离散的dirichlet能量计算的模型函数变异性的量度。使用理论论据和经验结果的结合，我们表明，许多常见的训练启发式方法，例如参数规范正规化，光谱规范正则化，平稳性正则化，隐式梯度正则化，噪声正则化和参数初始化的选择，都可以控制几何学复杂性，并提供一个统一的框架，以表征深度学习模型的行为。

步态冻结（FOG）是帕金森氏病的最常见症状之一，这是中枢神经系统的神经退行性疾病，影响了世界各地数百万的人。为了满足提高雾的治疗质量的紧迫需求，设计雾计算机辅助检测和量化工具的需求越来越重要。作为一种用于收集运动模式的非侵入性技术，从压力敏感步态垫中获得的脚步压力序列为评估诊所和家庭环境中的雾气提供了绝佳的机会。在这项研究中，提出了雾检测为一项顺序建模任务，并提出了一种新颖的深度学习结构，即对对抗性时空网络（ASTN），提出了跨多个级别的雾模式。引入了一种新型的对抗训练方案，并具有多级主题鉴别器，以获得独立的雾代表示，这有助于降低由于高主体间方差而导致的过度拟合风险。结果，对于看不见的受试者，可以实现强大的雾检测。拟议的计划还阐明了从其他场景中改善主题级临床研究，因为它可以与许多现有的深层建筑集成在一起。据我们所知，这是基于脚步压力的雾检测的最早研究之一，利用ASTN的方法是追求独立于主题的表示形式的第一个深神经网络架构。从21名受试者收集的393次试验的实验结果表明，AUC 0.85的雾检测提出的ASTN表现令人鼓舞。

ICECUBE是一种用于检测1 GEV和1 PEV之间大气和天体中微子的光学传感器的立方公斤阵列，该阵列已部署1.45 km至2.45 km的南极的冰盖表面以下1.45 km至2.45 km。来自ICE探测器的事件的分类和重建在ICeCube数据分析中起着核心作用。重建和分类事件是一个挑战，这是由于探测器的几何形状，不均匀的散射和冰中光的吸收，并且低于100 GEV的光，每个事件产生的信号光子数量相对较少。为了应对这一挑战，可以将ICECUBE事件表示为点云图形，并将图形神经网络（GNN）作为分类和重建方法。 GNN能够将中微子事件与宇宙射线背景区分开，对不同的中微子事件类型进行分类，并重建沉积的能量，方向和相互作用顶点。基于仿真，我们提供了1-100 GEV能量范围的比较与当前ICECUBE分析中使用的当前最新最大似然技术，包括已知系统不确定性的影响。对于中微子事件分类，与当前的IceCube方法相比，GNN以固定的假阳性速率（FPR）提高了信号效率的18％。另外，GNN在固定信号效率下将FPR的降低超过8（低于半百分比）。对于能源，方向和相互作用顶点的重建，与当前最大似然技术相比，分辨率平均提高了13％-20％。当在GPU上运行时，GNN能够以几乎是2.7 kHz的中位数ICECUBE触发速率的速率处理ICECUBE事件，这打开了在在线搜索瞬态事件中使用低能量中微子的可能性。

在本文中，使用聚类和阈值算法实现了DIBA数据集细菌属和物种的半自动注释。深度学习模型经过训练，以实现细菌物种的语义分割和分类。分类精度达到95％。深度学习模型在生物医学图像处理中发现了巨大的应用。从革兰氏阴性微观图像中自动分割细菌对于诊断呼吸道和尿路感染，检测癌症等至关重要。深度学习将有助于生物学家在更少的时间内获得可靠的结果。此外，可以减少许多人类干预措施。这项工作可能有助于检测尿液涂片图像，痰液涂片图像等的细菌，以诊断尿路感染，结核病，肺炎等。

唇裂是一种先天性异常，需要专家手术修复。外科医生必须具有丰富的经验和理论知识才能进行手术，并且已经提出了人工智能（AI）方法来指导外科医生改善手术结局。如果可以使用AI来预测修复的唇唇的外观，那么外科医生可以将其用作辅助手术技术来调整其手术技术并改善结果。为了在保护患者隐私时探索这个想法的可行性，我们提出了一种基于深度学习的图像镶嵌方法，该方法能够覆盖唇裂，并产生唇彩，而无需裂缝。我们的实验是在两个现实世界中的裂口数据集上进行的，并由专家cleft唇外科医生评估，以证明该方法的可行性。

我们解决以下动作效应预测任务。给定描绘世界初始状态和文本中表达的动作的图像，预测了动作后描绘世界状态的图像。预测应具有与输入图像相同的场景上下文。我们探讨了最近提出的GLIDE模型执行此任务的使用。Glide是一个生成性神经网络，可以合成图像的掩盖区域（涂层），以短片段为条件。我们的想法是掩盖预期动作效果的输入图像的区域。然后使用滑行以在所需动作为条件的蒙面区域内涂抹涂漆。这样，结果图像具有与输入图像相同的背景上下文，并更新以显示动作的效果。我们使用带有动作标记的自我中心视频的Epic数据集给出了实验的定性结果。